is reconstitution solution the same as bacteriostatic water?

Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. and ADVERSE REACTIONS. Those are bacteriostatic and sterile water. Stability data should be reviewed and the justification of the expiration date should be based on batches with the higher moisture content. Bacteriostatic Sodium Chloride: Package Insert - Drugs.com Plus, peptide solutions made with bacteriostatic water resist contamination. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS. You can go as high as 2 milliliters per peptide reconstitution as it does no harm other than more dilution. Where water is required for preparing or diluting medications for use in neonates, only preservative-free Sterile Water for Injection should be used. How to use reconstitute in a sentence. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. IMPORTANT - Use only Bacteriostatic Water for Injection with Benzyl Alcohol . PDF Methylprednisolone Sodium Succinate for Injection, USP For Intravenous When reconstituted with Bacteriostatic Water for Injection, USP, the resulting solution must be used within 7 days. Provisions for sterilizing and assuring the integrity of vent filters or filters used to sterilize the inert gas and air. Obviously, the batching or compounding of these bulk solutions should be controlled in order to prevent any potential increase in microbiological levels that may occur up to the time that the bulk solutions are filtered (sterilized). Sterile water usually comes in single-unit doses and the reuse of units is prohibited. That means, they are single-dose vials and should be discarded after a single-use. The pH is 5.7 (4.5 to 7.0). There are not many side effects associated with using bacteriostatic water. Verified Purchase. Slowly extract the bacteriostatic water until the solution reaches your desired level. But, for long-term storage of the powder form, the required temperature is less than -20 degrees celsius. On the other hand, a sterile water vial doesnt contain any preservatives/additives which can keep it free of pathogens for a longer time, thus one will have to use it immediately after opening the seal. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Consult with pharmacist, if available. It is only used for injections such as intravenous, intramuscular and subcutaneous. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. First, you want to thoroughly wash your hands with soap and water for at least 20 seconds. Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthesia procedures. If kept under appropriate conditions, bacteriostatic saline can last up to 28 days. Another difference is indications. Is Bacteriostatic Water The Same As Sterile Water? You can email the site owner to let them know you were blocked. 62.5 mg/mL, 3.2 mL b. There have been times when sterile water has been in short supply. PHARM TEST #2: Reconstitution Flashcards | Quizlet Our focus is to exclusively link to peer-reviewed studies found on respected websites, like PubMed. To do the reconstitution you will need: Vial . However, when excipients or other additives are present, weight variation may be applied provided there is correlation with the sample weight and potency results. Bacteriostatic water is better when diluting any medication because it offers better solubility for the most part. As I mentioned at the start, the sterile water vial doesnt contain benzyl alcohol which makes it unfavorable for storage. If symptoms appear, injections should be discontinued pending medical consultation [9]. With the presence of 0.9% benzyl alcohol, the shelf-life of a bacteriostatic water vial is considerably increased up to 28 days as it will prevent the growth of any bacteria. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination. So, if you are someone who has seen the vials of both types of water, I am sure you can now understand why a bacteriostatic water vial contains considerable volume while a sterile water vial contains just a few milliliters. Although products may be labeled for reconstitution with Bacteriostatic Water for Injection, Sterile Water for Injection (WFI) should be used to reconstitute products. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. Morgan, SL and Spotts, MR; "How to Select a Pharmaceutical Freeze-Drying System"; Pharmaceutical Technology, volume 3, No. Gather the following: alcohol swabs, bacteriostatic water, peptide powder, and a sterile syringe. It is essential to avoid exposure to light and high temperatures, which can lead to peptide degradation. Overall, specialists agree that bacteriostatic water for injection is safer and more effective in most cases. In case you have any issue diluting peptides in bacteriostatic water, you should add a small amount of 10% aqueous acetic acid for basic peptides and aqueous ammonia for acidic peptides. 1. However, you are not allowed to assign, transfer, or subcontract any of your rights and/or obligations under these Terms. Using the 28-29 gauge insulin syringe, you will have to draw 0.1 ml of water per injection. SIDE EFFECTS. Reddit and its partners use cookies and similar technologies to provide you with a better experience. To the extent that Peptides.org references a product that is also a prescription medication, Peptides.org does not does not offer medical diagnosis or treatment advice. New comments cannot be posted and votes cannot be cast. For safe storage, adhere to manufacturer indications. This website is using a security service to protect itself from online attacks. Water balance is maintained by various regulatory mechanisms. According to a recent study, 99.9% of people struggle with this step. Bacteriostatic Water for Injection, USP must be made approximately isotonic prior to use. Dont wait to enjoy the benefits of bacteriostatic water for injections. Before digging deeper into precise conditions required to store peptides, you should know that keeping a peptide vial away from intense light, high temperature and moisture is a MUST. May contain hydrochloric acid for pH adjustment. Administration of an estimated 9 mL to a 6 kg infant or neonate is potentially capable of producing blood pressure changes. There is no sort of preservative or antimicrobial agent added to it. Why is Water Essential to Reconstitution? This website is using a security service to protect itself from online attacks. Package insert / product label Bacteriostatic 0.9% Sodium Chloride (NaCl) Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. How many mL are required for one dose? Bacteriostatic water (BW) has a pH of about 5.7. Two sterile solutions that are commonly used are bacteriostatic water and sterile water. All rights reserved. Researchers also use organic solvent such as Acetic acid and DMSO to dissolve hydrophobic peptides and polar uncharged amino acids. In the event these should occur, re-evaluate the patient and institute appropriate corrective measures. Reconstitution Definition: 569 Samples | Law Insider Storing peptides is a very crucial step because a slight fluctuation in the physical conditions can really degrade the peptide vial. Reconstitution Solution versus Bacteriostatic Water. BACTERIOSTATIC WATER Rx only 3977). It is not intended nor implied to be a substitute for professional medical advice. RxList does not provide medical advice, diagnosis or treatment. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. By using this Website, you agreed to accept all terms and conditions written in here. Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). This article will guide you step-by-step on how to mix your peptides well enough and will clear all your questions so that you can enjoy the maximum efficacy of peptides. Our goal is to provide you with the most scientifically accurate, unbiased, and comprehensive information regarding all research peptides and SARMs. Handlers should follow the applicable dosage and administration schedule [16]. All of our content is written by people with a strong science background, including medical researchers. Intravenous administration of Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection without a solute may result in hemolysis. Its like a chemistry experiment, but instead of blowing things up, youll be improving your health. 29-31, 48; 1986. You'll need an alcohol wipe, your bacteriostatic water and HCG vials, your reconstitution syringe and needle, and a Sharps container for safe disposal. While you can go on to use the conventionally manual way to reconstitute peptides, it gets a whole lot easier to use the reconstitution calculator, and get the right dosage! FDA indications vary regarding drug interactions. 1. : the action of reconstituting or state of being reconstituted. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. One vial of BPC 157 contains 5mg, which also means 5000mcg. Available for Android and iOS devices. The choice is purely up to the user which solution to use. Reconstitution follows the above method. There is literally no other option. Because visual guidance is far better to approach, I searched for some of the Youtube videos that could help you in the process. Bacteriostatic water and sterile water can be used in intravenous, intramuscular and subcutaneous injections. This thread is archived In these Website Standard Terms and Conditions, Your Content shall mean any audio, video text, images or other material you choose to display on this Website. How to Properly Reconstitute AOD 9604 + Dose Measurement Bacteriostatic water is water with benzyl alcohol. The concern with any microbiological level is the possible increase in endotoxins that may develop. 94-101, 114; 1979. This is the method of peptide reconstitution with bacteriostatic water for injection [13]: Human growth hormone has a range of therapeutic applications, from enhanced physical composition and performance, to treatment of hormone deficiency in adolescents and children [14, 15]. Bacteriostatic water solutions remain sterile and safe for longer due to the preservative agent. Management of Drug Shortages with 0.9% Sodium Chloride, Sterile Water This bacteriostat is usually 0.9% benzyl alcohol. The .gov means its official.Federal government websites often end in .gov or .mil. Bacteriostatic Water for Injections | The A-Z Guide, Add a header to begin generating the table of contents. You use AA, wich is a .6% solution of acetic acid. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. In summary, the best way to store reconstituted peptides depends on the duration of storage and the desired shelf life. Bacteriostatic waters preservative content prevents contamination for multiple doses, while sterile water may be contaminated after one use. For intravenous infusion, first prepare solution by adding not more than 2 mL of Bacteriostatic Water for Injection to the vial; this solution may then be added to 100 . I am sure that most of the things would be clear by now. What Is Bacteriostatic Water For Peptide Reconstitution We comply with the HONcode standard for trustworthy health information. Yes, distilled water can also be used to reconstitute peptides alongside the bacteriostatic and sterile water. This parenteral preparation is unlikely to Water for Injection, USP is chemically designated H2O. The benzyl alcohol in the water makes bacteriostatic water ideal for diluting any drug that will be administered by intramuscular, intravenous, or subcutaneous injection. Due to the pH, a more apt solution for fluid replacement is normal saline or dextrose. Bacteriostatic water has a 0.9% benzyl alcohol content and an average pH level of 5.7, while sterile water is free of additives with a pH level of 5.0-7.0. Bacteriostatic Water (Bacteriostatic Water for Injection - RxList Sterile water is free of any organic materials but contains inorganic materials to some extent. Bacteriostatic Water may be used alone or with other medications. The next step is to do is add the mass of the peptide in mg that you want to reconstitute (This is generally going to be listed on the peptide vial) with the x ml of bacteriostatic water in order to get your desirable dosage in mcg. Good practice and a good quality assurance program would include the frequent monitoring of the volume of fill such as every 15 minutes. 420 Throckmorton Street, Suite 200, Fort Worth Texas 76102, Copyright 2022 BacteriostaticWater.com - All Rights Reserved, Wholesale Hospira Bacteriostatic Water Supplier, Need help? Some of the older lyophilizers cannot tolerate steam under pressure and sterilization is marginal at best. Do not use Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP for intravenous injection unless the osmolar concentration of additives results in an approximate isotonic admixture. Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. Bacteriostatic water is usually the term given to a commercial preparation (made by Hospira, for example), whereas reconstitution solution is the term given by a smaller (usually underground) company that makes its own to sell. Read more. Made with the organic preservative benzyl alcohol, this solution resists contamination to enable multiple doses per vial. It is only used for injections such as intravenous, intramuscular and subcutaneous. Air oxidation is yet another threat to the efficacy of the peptide, especially some peptides having amino acids such as free cysteine and tryptophan. The benzyl alcohol in it would cause red blood cell lysis. Some of the important aspects of these operations include: the formulation of solutions; filling of vials and validation of the filling operation; sterilization and engineering aspects of the lyophilizer; and testing of the end product. Would love your thoughts, please comment. Generally lyophilized products have short expiration dates. Mrose . These formulations are less expensive to produce and more widely available than comparable products, such as sterile water [3]. HGH Mixing Reconstitution 1. If the peptide still doesnt get dissolved, perform trial and error and use various other solvents. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. There are only two kinds of water that are most safe to reconstitute peptides. If you are interested in using bacteriostatic water for injections, look no further! Please refer to the WARNINGS Your IP: If any provision of these Terms is found to be invalid under any applicable law, such provisions shall be deleted without affecting the remaining provisions herein. (Isotonic saline = 0.28 osmolar.) It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. Sample 1 Sample 2 Sample 3. Bacteriostatic water differs from sterile water by the addition of benzyl alcohol as a preservative with a final concentration of 0.9%. What is the difference between bacteriostatic water vs. sterile water for injection? The action you just performed triggered the security solution. Insert your needle tip into the sealed bottle of bacteriostatic water. Most peptides that you will see are often sold as lyophilized peptides which means that (freeze-dried) powder form. Pregnancy: Animal reproduction studies have not been conducted with Bacteriostatic Water for Injection. This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. FDA rev date: 6/15/2000. I recommend using bacteriostatic water since that's what the peptide vendors sell and recommend. 2. : regeneration of an organic form by reorganization of existent tissue without blastema formation. As the title suggestswhats the difference between bacteriostatic water and reconstitution solution? Prior to buying anything, check that it is compliant where you live with your current government laws. Do not agitate the solution, which can damage the peptides. . While most of the peptides will be soluble in bacteriostatic water and sterile water, some really wont, and this will be depending on the polarity of the peptides. No information provided. Bacteriostatic water is a sterile form of water that has been brought to a pH between 4.5 to 7.0. (WITHOUT GRABBING YOUR FREE COPY OF THE SARMS AND PEPTIDES SECRETS MINI COURSE). Only if the peptides are of the same nature such as growth hormone (GH) influencers or if you see any vendors selling a stack of particular peptides, only those you should mix. Adverse reactions are rare and can include fever, infection, and thrombosis. Research peptides present great potential in emerging clinical contexts, such as combating symptoms of cardiovascular and metabolic diseases, as well as improving reproductive health [11]. Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. How To Reconstitute PT-141 In Bacteriostatic Or Sterile Water [See USP Controlled Room Temperature. 100 mg Plain. Long-term storage: For long-term storage, it is recommended to aliquot the reconstituted peptide into small volumes and freeze them at -20C or -80C. The container requires no vapor barrier to maintain the proper labeled volume. The second step is to use your syringe and draw out 1ml of bacteriostatic water from the vial without really touching the needle as it could cause contamination. Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. Last reviewed on RxList: 10/13/2021 When it comes to reconstituting peptides, there is a common question of whether bacteriostatic water is the same as sterile water. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. The preservative agent (0.9% benzyl alcohol) in bacteriostatic water allows packaging in multi-dose vials that resist contamination for up to 28 days when used with sterile needles. BACTERIOSTATIC 0.9% SODIUM CHLORIDE INJECTION, USP 10mL VIAL Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects. Curious about Bacteriostatic Water for injections? Medically reviewed by Drugs.com. swelling of your face, lips, tongue, or throat, redness, warmth, and pain at the injection site, tenderness or irritation at the injection site. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. Experts state that it may be necessary to run trials in order to select the best solvent for various peptides, and sodium chloride water should be avoided [12]. Besides, to avoid the degradation of peptides from moisture, allow the reconstituted peptide vial to come at room temperature after pulling it out from the refrigerator. As discussed earlier, peptide mixing water is used to dissolve/dilute the lyophilized peptides. EZCORE INTERNATIONAL PVT. As mentioned previously, sterile water only has distilled water and nothing else. These lyophilizers can only have their inside surfaces wiped with a chemical agent that may be a sterilant. The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection. Products are manufactured in the lyophilized form due to their instability when in solution. Bacteriostatic Water for Injection Prescribing Information. 2) Decide how much reconstitution liquid you want to use to convert your lyophilized peptide into an injection-ready solution, and calculate the concentration of the solution. From medications to peptides and hormones, bacteriostatic water is a winning option when it comes to reconstitution and sterility. It is a copolymer of ethylene and propylene. With patients having the autonomy to take medications at home at their own comfort, the education on these sterile solutions is crucial. The process of reconstitution is the same regardless of what kind of water you chose to reconstitute your AOD with. Validation of this handling should also include the use of filled vials of media. This guide has you covered. Water balance is maintained by various regulatory mechanisms. In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. PDF SOLU-MEDROL (methylprednisolone sodium succinate) Label - Food and Drug
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